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Project: ORLAB/150301
duration: 01/03/2015 - 28/02/2017
status: Archive/Self-Financing
Title: Applied Optimization in Brachytherapy Treatment Planning
Principal Investigator: Kaveh Sheibani
Affiliation: ORLab Analytics, Canada
contacts: orlab@orlabanalytics.ca

abstract. Brachytherapy (also known as internal radiotherapy) is a form of cancer treatment where a radiation source is placed at short distances from the target cells (tumor). Radioactive substances come in several different forms such as wires, tubes, ribbons, needles, capsules, seeds or other devices. Depending on the type of implant, the radiation source will stay in place temporarily or permanently. Brachytherapy is commonly used as an effective treatment option for many types of cancers alone or in combination with other treatments such as surgery, external beam radiotherapy and chemotherapy. Effective brachytherapy requires a treatment plan that delivers a prescribed dose to tumor while simultaneously limiting the dose to critical normal tissues (organs-at-risk). Different optimization techniques (in operational research) for brachytherapy treatment planning, such as mathematical modeling, heuristics or meta-heuristics have been considered. The outcome (purpose) of this project, is to provide a survey on the subject.





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